Scientists Propose Living to 150 Years Old is Not Far Fetched Anymore 
 
Living to 150 – just the idea of it struck me as not only impossible but undesirable. Why on earth would I want to live past 100, if the next 50 years were filled with disability and dementia? But the idea has tremendous appeal to David Sinclair, PhD, longevity researcher at Harvard and author of Lifespan: Why We Age and Why We Don’t Have To. When I discovered that many of my doctor and nurse friends were reading Sinclair’s bold vision of the future, I decided I had to see how this latest longevity book compared to the current rash of anti-aging ideas pitched today. 
 
It was the endorsements that first grabbed my attention.  Three pages of names – from Dean Ornish to Mark Hyman to Dale Bredesen--extolling Sinclair’s treatise as the last health book you’ll ever have to read, with comments like “stepping on the moon,” “a tour de force,” “the most important message of our time.”  Wow. I was under the impression that a gentler, kinder zeitgeist had entered the cultural conversation with expert critiques of over-medicalization and appeals for comfort care over end-of-life heroics. What’s this renewed interest in living so long?
 
Aging has never been popular in the U.S. We seem culture-bound to buy any product or trend that promises to halt our telomeres from fraying or keep our gut microbiome from raising hell. We ponder anti-aging advice from celebrities like Suzanne Somers as she pushes bioidentical hormones. 
 
From obsessive paleo diets to centenarians living in Blue Zones, I’ve been reporting the latest breakthroughs on the aging front for several decades. Remember Aubrey de Grey? The longevity researcher with the Rip van Winkle beard? He announced 20 years ago that his rejuvenation alternative would make him as old as Methuselah.  Then when scientists discovered how pesky free radicals damaged DNA, inventor Ray Kurzweil started swallowing about 120 antioxidant supplements a day, giving rise to legions of tech-savvy biohackers.
 
Now, according to Sinclair, those theories of why we age prematurely are outdated. Antioxidants do indeed scavenge those pesky free radicals that damage chromosomes, but now it appears that free radicals also do some good. Basic science has moved forward. 
 
A New Theory of Aging
His new “theory of everything” is an information theory that supports the entire theme of Lifespan—that aging is a disease. The book, written with Matt LaPlante, gives credit to over 60 international scientists who are each contributing a part of that information puzzle.  Sinclair calls this collection of findings and extrapolated hypotheses the 9 Hallmarks of Aging.  (see sidebar)

What Actually Makes Us Age?
Here are the 9 factors that when combined, make us “age”
1. Telomere attrition
2. Mitochondrial dysfunction
3. Stem cell exhaustion
4. Altered intracellular communication and production of inflammatory molecules
5. Loss of proteotosis (protein maintenance)
6. Senescent cell accumulation (cells that don’t fully die off, wander around where they shouldn’t, causing problems)
7. Deregulated nutrient sensing (decreased ability to monitor nutrients like sugar, lipids, amino acids)
8. Alterations to the epigenome (chemical compounds and proteins that can attach to DNA and direct such actions as turning genes on or off, controlling the production of proteins in particular cells)
9. Genetic instability (genetic mutations that interfere with repairing DNA, i.e., BRCA1 and BRCA2)
 
Now with groundbreaking but complex research findings at the nano level, it’s harder for the average health-conscious consumer to follow. With instantaneous genome mapping, and amazing CRISPR technology allowing scientists to replace one gene at a time, scientists can venture deeper into cellular mysteries. Researchers can monitor several new pathways of aging, like the mTOR pathway, which regulates how cells can be dormant (quiescence), or die off (senescence) or reactivate as stem cells. Scientists just discovered a sort of “aging dance” of DNA loops, known as TADs (Topologically Associated Domains). They have figured out how to remove troubling, cancer-inducing methyl groups off of chromosomes, (hence the expression at Functional Medicine meetings, “If you’re a poor methylator, you might be a cancer-maker”). Very recently they are able to manipulate certain enzymes to reprogram the way our cells respond with characteristic youthful markers instead of typical aging. 

Have I lost you yet?  
 
This is what it’s like plowing through Sinclair’s book – truckloads of scientific jargon and biochemistry. Finally, there was one chapter that had me hooked. One of Sinclair’s post-docs had a major breakthrough in longevity research when he crushed a mouse’s optic nerve, then injected three of the four enzymes (known as Yamanaka factors) into a virus, then injected the virus into the mouse, and witnessed over time, the nerve growing back, restoring sight.  Downright miraculous, declared Sinclair’s team. (We owe a lot to lab mice.)
 
Optic nerves don’t just regenerate, but his lab managed to demonstrate that they can.  Glaucoma and vision loss are serious conditions of aging eyeballs.  Wading through the compilation of biochemistry is this book made me realize why it garnered the over-the-top endorsements.
 
Still, we want the bottom line and ask: Ok, but what can I do now?
 
Sinclair is careful to not make recommendations in his book but he talks about putting his elderly father on the same personal regimen with good results, namely:  a plant-based diet, no desserts, exercise, one gram of NMN (nicotinamide mononucleotide), one gram of metformin and assorted other supplements. While anecdotal tales don’t make for good science, Sinclair hopes to conduct a first human clinical trial within a few years, not on extending lifespan, but on glaucoma. 
  
 
Activating Your Longevity Pathways
 
Science has taken great strides into understanding new pathways of aging. Perhaps the most pertinent finding is that mice and humans  (maybe other mammals) have built-in longevity pathways that we can be activated with either a molecule called NMN or NR, nicotinamide riboside.  
 
Metformin, a prescription-only pharmaceutical drug prescribed for diabetes, also seems to favorably impact the built-in longevity pathways. Doctors have known for some time that patients on metformin don’t seem to get Alzheimer’s or certain cancer or heart disease at the same rate as others their age.
 
 
What makes good science?
 
The longevity mystery has just become more complex and the jury is still out as to whether this new cluster of information is actually extending life. In fact, Charles Brenner, PhD, the scientist who discovered NR, told me, “Sinclair is a great storyteller, but his hypothesis is not testable. He doesn’t have a falsifiable hypothesis.” 
 
Science makes progress by working with falsifiable hypotheses—these are statements that have the capacity to be proven wrong, an essential feature of the scientific method. For example, the statement: take these supplements and your life will be longer. So does that mean that the opposite is true? Not taking these supplements will shorten your life?  Uh, no, you can’t prove that so you can’t call it good science.
 
But that hasn’t stopped Sinclair or dozens of others excited about research on sirtuin, the family of proteins that regulate cellular health. There are seven types of sirtuins and at least four are known metabolic regulators that control gene expression. Sirtuins are to this decade what antioxidants were to the ‘90s—the latest darling in the quest for causal factors of aging.
 
Brenner discloses that he has a vested interest in the patented substance, nicotinamide riboside, commonly called NR.  Both NR and the molecule that Sinclair takes, NMN, are precursors to a fundamentally important molecule, nicotinamide adenine dinucleotide
 (in its oxidized form abbreviated NAD+), which is in every cell of your body, but starts to decline at about age 40 or 50, depending on how deleterious your lifestyle is (i.e., sun damage, chemo/radiotherapy, poor diet, sedentary).
 
Brenner has other problems with Sinclair’s ideas.  Promoting wide scale use of metformin does not strike him as sound.  “If people are looking to age better, we know that high levels of physical activity, mental and social engagement are positively associated with wellness. We have recently learned that metformin blunts improvements in physical fitness due to exercise. My reading of the literature says that healthy people should not take metformin.”
 
Brenner also warns that “we don’t know what’s in some of the NMN capsules going around. We know for a fact there’s a company with an NAD-boosting product that adds caffeine, nicotinamide, and Vit C, and perhaps unknown contaminates. The caffeine alone might account for why people report feeling energized.” Others contain ingredients that may boost cholesterol levels. “The only supplements people should take are ones with proven safety trials from clean, inspected labs.”  
 
5 Things That May Increase Your Longevity
 
1. Fast Intermittently. – Try to be a little hungry each day. Stop any late-night snacking. Then go from your dinnertime to eating a late lunch— skipping breakfast. Aim for 12 hours of fasting to start. Stretch to 16, or try two days a week with 500 calories or less.
2. Eat a primarily plant-based diet.  Cutting back on meat means that you are lowering the amount of amino acids, which your body recognizes as hunger, creating slight starvation.  This is all about not over-activating the mTOR pathway. If it’s overactive, you’re at greater risk for heart disease, Alzheimer’s, and certain cancers.
3. Give up your thermonuclear comforts.  Try to be shivering cold at least once a day. Scientists don’t fully understand why being cold is linked with turning on longevity pathways. I found this one to be wildly unpopular among my women friends, who may all have compromised thyroids.
4. Exercise, of course. Adjust it to high intensity interval training (HIIT). After a brief warmup, force your heart rate to climb as you fully exert for 30 seconds, then recover back to near-resting levels for 90 seconds. Repeat 6 to 8 cycles. This will take less than 15 minutes, 2–3 times a week.
5. Boost your NAD levels with a proven nicotinamide riboside, such as Niagen, or NMN.
 
So that’s the good news.  We alter the epigenome and thus, genetic expression, according to Sinclair, when we shiver, are hungry, and move a lot.  Contemporary life is not so great for us, since it dampens this long-life genetic activity. 
 
Really? I can hear my epidemiology colleagues saying, “ridiculous.”  The strides in public health, sanitation, clean water, agricultural and protein production, infection control, vaccination, first responder networks, have all extended the average lifespan, primarily by reducing infant mortality.
 
This leads me to conclude that for us health-conscious folks who have a pretty good life and want to be around to enjoy it fully without disability, dementia or despair, these lifestyle adjustments might be worth the discomfort. Aging with grace, dignity and a youthful spirit – that seems to be a personal choice, no matter what you swallow.
 
#  #  # 
 

 I served on one of first vaccination teams in December at a SNF with an active COVID outbreak, setting up the mobile clinic in an outdoor courtyard, on a chilly day. We took no breaks because we didn’t want to don and doff our PPE--a feat of endurance. We set up four stations: registration/counseling,  vaccination tables, recovery area. I noted how smoothly my RN colleagues, all former or current ICU or ER nurses like myself, moved into action together, even though we never met till that morning. It was a familiar, no-nonsense rhythm of providing what was critically needed, and a welcomed break from the social-political obsessions I experienced most days of 2020.

When the public health official arrived with the refrigerated case of Pfizer-BioNTech COVID-19 vaccine, we gathered around to open it. Wow. We beheld the rows of tiny purple-capped vials, and a wave of emotion swept over the entire team. Maybe because these were among the first vaccines to arrive in Marin County, maybe because it was the day before Christmas Eve, and we were huddled together in a SNF courtyard strung with paper Christmas decorations, but there was no denying that we felt like something precious and rare and long sought after was in our hands. It was viewed as a very privileged and sacred moment, a chance to end this epidemic of sickness, death and loneliness. I gingerly picked up one vial with a double gloved hand and joked, “Look at us, we look like we’re gazing at baby Jesus, as if a Christmas miracle had arrived!” And true to form, we burst out laughing, a typical response of front-line health care personnel to break the tension and get back to work. 

You might wonder if we were there to vaccinate the frail elderly residents.  No, just the staff. California follows the CDC recommendations to first vaccinate the most at-risk which aren’t the non-ambulatory residents, but the staff—the nursing aids, orderlies, cooks, cleaners and janitors of nursing homes and SNFs. These folks are often new immigrants, people of color with higher rates of chronic disease, who work for low wages due to minimal education or lack of documentation. They work hard holding onto the only job they could get without specialized credentials, and they do their best in the poorest of conditions. They are most at-risk from an epidemiological viewpoint, taking public transit back and forth to crowded living conditions, frequenting stores or working extra shifts at essential service jobs, in contact with hundreds of people each week, and also going room to room at the SNF, sometimes in more than one facility.

But it wasn’t always easy to convince staff to get the shot. While a few gladly rolled up a sleeve, several heard about a “lack of testing” or that “it gives you the disease.” We had to listen patiently, try to dispel fears and misinformation. Once a threshold of staff started lining up, the tide was turned and we jabbed away. While most people I talk with are thrilled to know that the vaccine is available for everyone, there are still those who are fearful or hesitant, and in those cases, I offer this moment of mindful reframing. Consider transmuting that worry with the current fact-based reality, that the world is participating in a massive coordination to bring a remarkable vaccines everywhere…the culmination of the work of thousands--scientists, virologists, clinical investigators, immunologists, epidemiologists, refrigerant engineers, delivery and dissemination experts, independent medical advisory boards, government and private enterprise partners, dedicated public servants, extraordinary public health leaders—and it is amazing that it winds up in the hands of volunteers like me willing to reach out and ask you to roll up your sleeve for a healthier, safer, happier world than what we’ve experienced since the start of 2021.

 Remember when energy drinks appeared two decades ago with enough sugar and caffeine in one can to fuel an NFL team for a season? Health conscious individuals took one sip of the first tachycardia-inducing formulas and switched to water with lemon.  Last year, a sample of 72 college students by Global Medicine Enterprises discovered that fit-minded millennials and Gen Zs would rather stain their stainless steel water bottles with a little fruit juice than stay hopped up on Red Bull for the rest of their anxious lives.
While the big soda makers like Pepsi and Coca-Cola compete for a dominant share in the still-growing energy drink market by offering healthier alternatives, the American Beverage Association discovered from a recent focus group that people were still up for energy drinks as long as they featured safe, healthy and natural ingredients. The respondents also thought there was too much caffeine and too much High Fructose Corn Syrup in most drinks.
I generally prefer water during and after my workouts. But there are times when I need an energy boost because I've overdone it, and then I look for an energy drink that meets my desire to only put healthy ingredients in my body. The latest offerings from a host of forward-thinking companies feature low sugar or no sugar, definitely no High Fructose Corn Syrup, and a wide array of desirable nutrients. 
Have you seen this summer's explosion in the refrigerated grocery shelves for chocolate flavored reishi mushroom drinks and lemonade with ashwagandha? A dizzying choice of high-powered, flavored Kombucha drinks (mojito flavored!), now sporting alcohol labels take up an entire end-cap at my local grocery store. 
One of the first energy drinks on the market, Monster Energy, was introduced by Hansen Beverages in 2002. Now owned and marketed by Monster Energy on 1 Monster Way in Corona, CA, the company, which also brings you Monster Sports, has come out with drinks that have zero or low sugar offerings, and others that feature 100 percent of daily value for viatmin B-12, niacin, riboflavin, and vitamin B-6.  Many of their drinks contain  Taurine, L-Carnitine and Inositol, which take part in energy transcription factors for optimal metabolism, but not more Inositol than you would find in an infant formula, comparing ounce-for-ounce. 
So it's possible today, thanks to consumer pressure, to quickly get your hands on a bad ass energy drink, featuring slow-brewed green tea that the legendary Chinese herbalist Emperor Shennong would gladly imbibe.
The good news here is that it's apparently safe for you to return to energy drinks.  I'm still hoping that the makers eliminate the sucrolose, a sugar alcohol that gives half of us some mild GI distress, but I understand the need to make an 8-ounce drink that boasts only 20 calories. The hunt continues for energy drinks that add a touch of monkfruit instead of sugar alcohols.
Your Global Medicine Hunter is still on the hunt, but less thirsty

New youtube video on children and amphetamines.
We are addicting our children to speed. It all starts with a questionable diagnosis of ADHD, and then the prescription gets written for Adderall or Ritalin.  Soon a child learns that the only way to be acceptable or loved is to take drugs that alter his or her behavior.  The problem is reaching epidemic proportions. There are safer ways to achieve focus and clarity: sleep, diet, stress management, effective communication skills, exercise and some botanical and nutrient support.  I was happy to narrate this hard-hitting video, and write some supportive material at www.wellcorps.com.

(EarthTalk, E Magazine----)How is it that global warming could cause an increase in health problems and disease epidemics? Do we have any evidence that it is already happening?  -- Jim Merrill, Provo, UT


Global warming isn’t just bad for the environment. There are several ways that it is expected to take a toll on human health. For starters, the extreme summer heat that is becoming more normal in a warming world can directly impact the health of billions of people.


“Extreme high air temperatures contribute directly to deaths from cardiovascular and respiratory disease, particularly among elderly people,” reports the World Health Organization (WHO). “In the heat wave of summer 2003 in Europe, for example, more than 70,000 excess deaths were recorded.” ​

(SAN FRANCISCO---)  Neuroscience used to be the subject where geniuses flourished and the rest of us grimaced--but not anymore. Neuroscience is hot, and everybody from app designers to massage therapists claim to apply the latest findings
​
The last decade of neuroscience research has produced an explosion of novel approaches to track the bidirectional interfaces between the brain and all other cellular structures. Some of the neuroscience research heads toward cognition and behavior, and winds up informing the expanding field of Positive Psychology. This is where you'll find evidence-informed practices for mindfulness, meditation, breath work, and other forms of stress reduction

Medical Tourism: Sick Rx for Global Energy Consumption
SAN FRANCISCO---) Two social forces—the increase in medical tourism and the imperative to decrease fossil fuel consumption—are at loggerheads. For a privileged group of health-seekers considering a wellness holiday or face lift at a destination spa or hip replacements, it's easy to hop on an international flight to Rio or Mumbai or Singapore. For over a decade, that has been the prerogative of the elite traveler, who figures their contribution to the global economy offsets any bump in greenhouse gas emissions. 
That logic might be hard to argue since new job markets have sprung up in formerly impoverished areas. But what if the masses—the thousands of millions below the super-affluent—decided that distant lands were the places to see doctors, get health care, buy elective surgeries, and enjoy wellness tune-ups? What does that do for efforts to curb fossil fuel production and excessive energy consumption? 

An Integrative Wellness Approach
I”m happy to report this new book, two years in the making, is finally completed and available at https://www.createspace.com/3636817
Authored by Meg A Jordan, PhD, RN, CWP

Natural Pain Relief with DoDrops
(available at www.globalmedicinehunter.com)
DoDrops is a natural pain relief remedy that uses two patented processes, and puts carefully-selected, naturally-occurring compounds and botanicals right where they do the most good in balancing the chronic inflammation that can lead to aches and discomforts. 
DoDrops has a proven track record for reducing excess levels of 5-lipoxygenase (5-LOX) enzyme that breaks down Arachidonic acid to pro-inflammatory leukotrienes, responsible for attacking joints and tissues and implicated in most chronic disease formation. 
The product is a water-soluble combination of "Nature's WD-40" (Cetyl Myristoleate) and high grade botanicals used in indigenous societies in South America and Asia including Boswellia serrata, Sea Buckthorn and Sacha Inchi oils. She believes this remedy could lower the risk of prescription drug abuse and the risk of side effects from typical painkillers. 

Arachidonic Acid Troublemakers: Cow’s milk cheese
Aches and pains from chronic inflammation can make you rely on painkillers for life. Arachidonic acid is a primary fuel for chronic inflammation; you’ll find it in organ meats, egg yolk, and cheese. You can limit the intake or try to balance the pro-and-anti-inflammatory profile in the body. Most people just take pain killers, but the problem with taking most pain medication is twofold. First, the body develops tolerance to prescription pain medication, which forces patients to take higher doses, thus increasing the risk of addiction or dependency. Secondly, prescription and over-the-counter anti-inflammatories raise the risk of harmful side effects such as gastrointestinal bleeding or cardiovascular events.
I’m seeing young women routinely take ibuprofen for monthly cramps, and young soccer players practically overdose with daily Advil, Motrin or Nuprin. Aleve, which has serious allergic responses from blood in the urine to massive respiratory failure, is another abused OTC remedy. Then there are the non-opioid analgesics such as acetaminophen (Tylenol) and aspirins (salicylates) which do not reduce inflammation like NSAIDs, and we know inflammation is a central cause of pain and discomfort.

Avoid Late Night Snacking on Foods Loaded With Vegetable Oils 
Give Your Heart a Healthy Valentine This Month and Stay Away from the Polyunsaturated Fatty Acids 
For Immediate Release 
GLOBAL MEDICINE HUNTER NEWS 
Dr. Meg Jordan 
mjordan@ciis.edu 
415 599-5523 
SAN FRANCISCO)---A new examination of older research on dietary fats may startle those of you who love to snack on greasy popcorn saturated with vegetable oils (such as, safflower, corn, canola oils known as polyunsaturated fatty acids). You may be better off having some old-fashioned saturated fats, like a bowl of ice cream. 
February is National Heart month, and this new meta-analysis of research done decades ago was just released by the British Journal of Medicine. Researchers found that the use of dietary linoleic acid for secondary prevention of coronary heart disease should be roundly questioned. ​